Growth & profitability
- Revenue has grown 1644.5% per year over the past 2 years.
- Operating margin has contracted, at -148.6% in the latest year.
SEPN Financials Septerna, Inc.
3 years of revenue, profit, cash flow and balance-sheet history through FY2025, from SEC filings — with a computed, factual read of the trend. Updated Overview →
RevenueNet income
GrossOperatingNet
ROEROA
Free cash flow
CashTotal debt
OperatingInvestingFinancing
Key annual figures
| FY | Revenue | Net income | Gross M | Op M | ROE | ROA | FCF | Total debt | Cash |
|---|---|---|---|---|---|---|---|---|---|
| 2025 | $46M | -$49M | 0.0% | -148.6% | -12.8% | -8.2% | $110M | — | $121M |
| 2024 | $1M | -$72M | 0.0% | -7518.4% | -17.1% | -15.7% | -$70M | — | $238M |
| 2023 | $151000 | $4M | 0.0% | 1374.2% | -10.9% | 3.2% | -$42M | — | $88M |
RevenueNet income
GrossOperatingNet
ROEROA
Free cash flow
CashTotal debt
OperatingInvestingFinancing
Key quarterly figures
| Quarter | Revenue | Net income | Gross M | Op M | ROE | ROA | FCF | Total debt | Cash |
|---|---|---|---|---|---|---|---|---|---|
| Jun '26 | $27M | -$13M | 0.0% | -62.9% | -3.4% | -2.3% | -$22M | — | $85M |
| Mar '26 | $27M | -$9M | 0.0% | -50.1% | -2.3% | -1.5% | -$26M | — | $72M |
| Dec '25 | $24M | -$11M | 0.0% | -66.4% | -2.8% | -1.8% | -$15M | — | $121M |
| Sep '25 | $21M | $8M | 0.0% | 12.2% | 2.1% | 1.3% | $169M | — | $320M |
| Jun '25 | $119000 | -$25M | 0.0% | -24351.3% | -6.6% | -6.0% | -$20M | — | $189M |
| Mar '25 | $219000 | -$21M | 0.0% | -11831.1% | -5.4% | -4.9% | -$24M | — | $210M |
| Dec '24 | $212000 | -$21M | 0.0% | -11659.4% | -4.9% | -4.5% | -$22M | — | $238M |
| Sep '24 | $176000 | -$21M | 0.0% | -12812.5% | 23.5% | -11.8% | -$17M | — | $88M |
| Jun '24 | $370000 | -$17M | 0.0% | -4882.4% | 24.4% | — | -$13M | — | $131M |
| Mar '24 | $317000 | -$14M | 0.0% | -4886.4% | 27.3% | — | -$17M | — | $81M |
| Dec '23 | $118000 | $35M | 0.0% | 29082.2% | -90.9% | 26.7% | -$10M | — | $88M |
| Sep '23 | $33000 | -$11M | 0.0% | -36484.8% | 14.8% | — | — | — | $99M |
| Jun '23 | — | -$11M | — | — | 16.8% | — | — | — | — |
| Mar '23 | — | -$9M | — | — | 17.3% | — | — | — | — |
Valuation over time
How the market has priced SEPN against its own fundamentals since 2024-10 — each month-end's share price set against the most recent annual filing, so the multiple moves as price runs ahead of (or behind) earnings. Split-adjusted.
- The price-to-earnings ratio has risen from 255.0× (Oct '24) to 283.4× (Nov '24).
- The price-to-sales ratio has fallen from 7060.3× (Oct '24) to 43.9× (Nov '26).
P/E
P/S
Frequently asked questions
Is SEPN growing its revenue and profit?
Over the past 2 years, Septerna, Inc.'s revenue has grown 1644.5% per year. These are computed facts, not advice.
How much debt does SEPN have?
As of FY2025, Septerna, Inc. reported — of total debt against $121M of cash.
What is SEPN's profit margin?
In FY2025, gross margin was —, operating margin -148.6%, and net margin -106.4%.
Where does this data come from?
All figures are extracted from the company’s SEC EDGAR/XBRL filings — 10-K annual reports and 10-Q quarterly reports (use the Annual / Quarterly toggle). Quarterly figures are derived from the as-filed statements (year-to-date amounts are differenced into discrete quarters). Growth rates and ratios are computed by tradmap; nothing here is investment advice.
Source: SEC EDGAR / XBRL (10-K + 10-Q filings) · prices EOD (Databento), split-adjusted; price return — dividends not reinvested · growth rates, valuation multiples & ratios computed by tradmap. Valuation uses each month-end price against the latest annual filing. Informational only — not investment advice.