6 years of revenue, profit, cash flow and balance-sheet history through FY2025,
from SEC filings — with a computed, factual read of the trend.
Updated Overview →
Growth & profitability
Revenue has grown 22.2% per year over the past 5 years.
Operating margin has expanded, at -87.3% in the latest year.
Financial health
The company is unprofitable; at its current free-cash-flow burn it has roughly 1.2 years of cash runway.
Revenue & net income
RevenueNet income
Margins (gross / operating / net)
GrossOperatingNet
Return on equity & assets (ROE / ROA)
ROEROA
Free cash flow (CFO − capex)
Free cash flow
Cash vs total debt
CashTotal debt
Cash flow: operating / investing / financing
OperatingInvestingFinancing
Key annual figures
FY
Revenue
Net income
Gross M
Op M
ROE
ROA
FCF
Total debt
Cash
2025
$106M
-$81M
0.0%
-87.3%
-30.2%
-23.4%
-$35M
—
$41M
2024
$76M
-$123M
0.0%
-179.7%
-36.2%
-26.5%
-$112M
—
$66M
2023
$76M
-$119M
0.0%
-181.6%
-25.5%
-20.4%
-$121M
—
$158M
2022
$412M
$124M
0.0%
31.6%
25.2%
19.2%
$136M
—
$401M
2021
$27M
-$212M
0.0%
-808.2%
-85.0%
-54.4%
-$205M
—
$202M
2020
$39M
-$181M
0.0%
-481.3%
-44.0%
—
-$156M
—
—
Revenue & net income
RevenueNet income
Margins (gross / operating / net)
GrossOperatingNet
Return on equity & assets (ROE / ROA)
ROEROA
Free cash flow (CFO − capex, quarterly)
Free cash flow
Cash vs total debt
CashTotal debt
Cash flow: operating / investing / financing
OperatingInvestingFinancing
Key quarterly figures
Quarter
Revenue
Net income
Gross M
Op M
ROE
ROA
FCF
Total debt
Cash
Jun '26
$5M
-$45M
0.0%
-919.0%
-56.0%
-11.3%
-$32M
—
$179M
Mar '26
$2M
-$44M
0.0%
-1956.7%
-27.0%
-9.2%
-$46M
—
$244M
Dec '25
$3M
-$41M
0.0%
-1755.5%
-15.3%
-11.9%
-$11M
—
$41M
Sep '25
$28M
-$20M
0.0%
-80.1%
-6.1%
-4.9%
-$32M
—
$65M
Jun '25
$49M
$2M
0.0%
-1.4%
0.7%
0.6%
$12M
—
$98M
Mar '25
$27M
-$23M
0.0%
-94.5%
-7.0%
-5.3%
-$3M
—
$76M
Dec '24
$31M
-$24M
0.0%
-71.6%
-6.9%
-5.1%
-$42M
—
$66M
Sep '24
$16M
-$30M
0.0%
-213.8%
-8.1%
-6.1%
-$7M
—
$122M
Jun '24
$19M
-$38M
0.0%
-222.9%
-9.3%
-7.3%
-$26M
—
$71M
Mar '24
$10M
-$32M
0.0%
-376.9%
-7.2%
-5.7%
-$38M
—
$115M
Dec '23
$17M
-$14M
0.0%
-138.4%
-3.1%
-2.5%
$14M
—
$158M
Sep '23
$17M
-$29M
0.0%
-201.4%
-6.8%
-5.2%
-$44M
—
$94M
Jun '23
$7M
-$51M
0.0%
-772.8%
-11.4%
-8.5%
-$7M
—
$142M
Mar '23
$36M
-$24M
0.0%
-76.7%
-5.1%
-4.1%
-$84M
—
$182M
Dec '22
$402M
$309M
0.0%
79.4%
62.8%
47.7%
$327M
—
$401M
Sep '22
$3M
-$48M
0.0%
-1914.0%
-26.6%
-15.9%
-$74M
—
$96M
Jun '22
$5M
-$65M
0.0%
-1209.5%
-29.1%
—
-$57M
—
—
Mar '22
$2M
-$73M
0.0%
-3793.6%
-25.7%
—
-$60M
—
—
Dec '21
$20M
-$39M
0.0%
-205.6%
-15.7%
-10.1%
-$55M
—
$202M
Sep '21
$4M
-$61M
0.0%
-1387.1%
-21.7%
—
—
—
—
Valuation over time
How the market has priced ZYME against its own fundamentals since 2023-03 —
each month-end's share price set against the most recent annual filing, so the multiple moves
as price runs ahead of (or behind) earnings. Split-adjusted.
The price-to-earnings ratio has risen from 5.2× (Mar '23) to 5.9× (Dec '23).
The price-to-sales ratio has risen from 1.6× (Mar '23) to 20.0× (Sep '26).
Price / earnings (P/E)
P/E
Price / sales (P/S)
P/S
Frequently asked questions
Is ZYME growing its revenue and profit?
Over the past 5 years, Zymeworks Inc.'s revenue has grown 22.2% per year. These are computed facts, not advice.
How much debt does ZYME have?
As of FY2025, Zymeworks Inc. reported — of total debt against $41M of cash.
What is ZYME's profit margin?
In FY2025, gross margin was —, operating margin -87.3%, and net margin -76.6%.
What is ZYME's P/E ratio?
As of Sep '26, Zymeworks Inc. traded at a price-to-earnings ratio of about 5.9× (market cap ÷ latest annual net income). The valuation charts above show how its P/E, P/S have moved with the share price. These are computed facts, not advice.
Where does this data come from?
All figures are extracted from the company’s SEC EDGAR/XBRL filings — 10-K annual reports and 10-Q quarterly reports (use the Annual / Quarterly toggle). Quarterly figures are derived from the as-filed statements (year-to-date amounts are differenced into discrete quarters). Growth rates and ratios are computed by tradmap; nothing here is investment advice.
Source: SEC EDGAR / XBRL (10-K + 10-Q filings) · prices EOD (Databento), corporate-action-adjusted ·
growth rates, valuation multiples & ratios computed by tradmap. Valuation uses each month-end price
against the latest annual filing. Informational only — not investment advice.