PTGX Protagonist Therapeutics, Inc

$112.59 +0.95%

Healthcare · Pharmaceutical Preparations

Protagonist Therapeutics, Inc (PTGX) is a healthcare company in the Pharmaceutical Preparations industry, with a market capitalization of $7.2 billion. Shares last traded at $112.59, near their 52-week high. Over the past year the stock is up 103.8%. Net profit margin is -282.8%, below the peer median of -0.1%. Revenue declined 89.4% year over year.

Market Cap

$7.2B

Shares Out

64.3M

EPS (TTM)

$-2.22

P/E Ratio

—

P/S Ratio

157.36

P/B Ratio

11.05

Dividend / Share

—

Dividend Yield

—

52-Week High

$114.48

52-Week Low

$49.42

Volume

56,169

Avg Vol (3m)

32,203.508

Performance

+2.54%

+14.49%

+10.73%

+23.01%

YTD

+29.09%

+103.83%

Chart

Full chart →

Daily candles · volume · SMA(20)/SMA(50) · Databento EQUS.MINI.

Technicals

RSI (14)

63.24

SMA (50)

$102.29

SMA (200)

$87.50

Price vs SMA50

+10.07%

Price vs SMA200

+28.68%

ATR (14)

$4.69

Financials

Revenue

$46M

Net Income

$-130M

Gross Margin

—

Operating Margin

-343.6%

Net Margin

-282.8%

Return on Equity

-19.9%

Return on Assets

-18.7%

Current Ratio

17.76

Debt / Equity

0.01

Revenue Growth (YoY)

-89.4%

Latest reported annual period ending 2025-12-31 · SEC EDGAR/XBRL.

Recent earnings

Period	EPS (diluted)	Reported
Q1 2026	$0.05	2026-05-05
FY 2025	$-2.05	2026-02-25
Q3 2025	$-1.35	2025-11-06
Q2 2025	$-0.73	2025-08-06
Q1 2026	$-0.19	2026-05-05
FY 2025	$4.23	2026-02-25

Full earnings history →

Pharmaceutical Preparations peers

PTGX vs 14 industry peers (Pharmaceutical Preparations), by market cap.

P/S vs peers

157.36 / 3.54 med

+4348% premium

Net margin vs peers

-282.8% / -0.1% med

below median

1–14 of 14


LLY	Lilly (Eli)	$1.04T	50.16	15.88	31.7%	-1.17%
JNJ	Johnson & Johnson	$549.8B	20.51	5.84	28.5%	-2.42%
ONC	Beone Medicines Ltd.	$390.6B	1361.26	73.10	5.4%	+2.83%
ABBV	AbbVie	$382.5B	90.51	6.25	6.9%	-2.16%
MRK	Merck	$281.6B	15.43	4.33	28.1%	-1.30%
ABT	Abbott Laboratories	$154.3B	23.65	3.48	14.7%	+0.09%
PFE	Pfizer	$143.7B	18.50	2.30	12.4%	-2.89%
VRTX	Vertex Pharmaceuticals	$114.6B	28.99	9.55	32.9%	-1.63%
BMY	Bristol Myers Squibb	$110.3B	15.63	2.29	14.6%	-2.35%
REGN	Regeneron Pharmaceuticals	$63.4B	14.08	4.42	31.4%	+0.38%
ALNY	Alnylam Pharmaceuticals	$36.9B	117.57	9.93	8.4%	-1.66%
TEVA	Teva Pharmaceutical Industries Ltd	$36.6B	25.98	2.12	8.2%	-3.33%
ZTS	Zoetis	$33.1B	12.37	3.49	28.2%	+2.09%
RPRX	Royalty Pharma Plc	$23.1B	30.02	9.73	32.4%	-1.30%

Source: SEC EDGAR (fundamentals/EPS/dividends) · Databento EQUS.MINI (prices) · market cap & yield computed by tradmap. Informational only — not financial advice.