7 years of revenue, profit, cash flow and balance-sheet history through FY2025,
from SEC filings — with a computed, factual read of the trend.
Updated Overview →
Growth & profitability
Revenue has declined 65.9% per year over the past 5 years.
Operating margin has contracted, at -748344.4% in the latest year.
Financial health
The company is unprofitable and has less than a year of cash runway at its current free-cash-flow burn.
Revenue & net income
RevenueNet income
Margins (gross / operating / net)
GrossOperatingNet
Return on equity & assets (ROE / ROA)
ROEROA
Free cash flow (CFO − capex)
Free cash flow
Cash vs total debt
CashTotal debt
Cash flow: operating / investing / financing
OperatingInvestingFinancing
Key annual figures
FY
Revenue
Net income
Gross M
Op M
ROE
ROA
FCF
Total debt
Cash
2025
$36000
-$274M
0.0%
-748344.4%
-110.6%
-80.7%
-$151M
—
$60M
2024
$61000
-$343M
0.0%
-588123.0%
-89.6%
-69.9%
-$163M
—
$106M
2023
$130000
-$235M
0.0%
-190006.2%
-35.8%
-31.3%
-$166M
—
$146M
2022
$85M
-$183M
0.0%
-220.9%
-22.0%
-19.5%
-$194M
—
$124M
2021
$11M
-$250M
0.0%
-2016.7%
-26.9%
-22.2%
-$192M
—
$294M
2020
$8M
-$204M
0.0%
-2732.6%
69.9%
-22.5%
-$212M
—
$140M
2019
$657000
-$129M
0.0%
-15538.7%
116.4%
—
$23M
—
$97M
Revenue & net income
RevenueNet income
Margins (gross / operating / net)
GrossOperatingNet
Return on equity & assets (ROE / ROA)
ROEROA
Free cash flow (CFO − capex, quarterly)
Free cash flow
Cash vs total debt
CashTotal debt
Cash flow: operating / investing / financing
OperatingInvestingFinancing
Key quarterly figures
Quarter
Revenue
Net income
Gross M
Op M
ROE
ROA
FCF
Total debt
Cash
Sep '26
$3000
-$46M
0.0%
-1609833.3%
-23.6%
-16.6%
-$35M
—
$92M
Jun '26
$4000
-$45M
0.0%
-1183425.0%
-19.1%
-14.4%
-$34M
—
$73M
Mar '26
$2000
-$24M
0.0%
-2213050.0%
-8.8%
-6.9%
-$39M
—
$91M
Dec '25
$6000
-$141M
0.0%
-2127400.0%
-56.7%
-41.4%
-$33M
—
$60M
Sep '25
$15000
-$39M
0.0%
-248353.3%
-11.8%
-9.5%
-$29M
—
$124M
Jun '25
$8000
-$43M
0.0%
-589250.0%
-14.3%
-11.1%
-$35M
—
$99M
Mar '25
$7000
-$52M
0.0%
-819528.6%
-15.5%
-12.1%
-$55M
—
$120M
Dec '24
$11000
-$192M
0.0%
-1828609.1%
-50.1%
-39.1%
-$47M
—
$106M
Sep '24
$34000
-$45M
0.0%
-148544.1%
-8.4%
-7.2%
-$35M
—
$100M
Jun '24
$13000
-$46M
0.0%
-396369.2%
-8.1%
-7.0%
-$38M
—
$133M
Mar '24
$3000
-$61M
0.0%
-1852500.0%
-10.1%
-8.7%
-$42M
—
$126M
Dec '23
$13000
-$53M
0.0%
-457753.8%
-8.1%
-7.1%
-$41M
—
$146M
Sep '23
$25000
-$51M
0.0%
-236156.0%
-7.3%
-6.4%
-$38M
—
$286M
Jun '23
$27000
-$64M
0.0%
-244092.6%
-8.7%
-7.6%
-$40M
—
$224M
Mar '23
$65000
-$67M
0.0%
-96240.0%
-8.5%
-7.6%
-$48M
—
$109M
Dec '22
$48M
-$8M
0.0%
-30.6%
-1.0%
-0.9%
-$45M
—
$124M
Sep '22
$3000
-$70M
0.0%
-2214566.7%
-8.6%
-7.2%
-$40M
—
$116M
Jun '22
$36M
-$36M
0.0%
-104.3%
-4.2%
-3.6%
-$52M
—
$206M
Mar '22
$553000
-$68M
0.0%
-12400.7%
-7.7%
-6.4%
-$58M
—
$223M
Dec '21
$3M
-$84M
0.0%
-1684.5%
-9.0%
-7.4%
-$43M
—
$294M
Valuation over time
How the market has priced LYEL against its own fundamentals since 2023-03 —
each month-end's share price set against the most recent annual filing, so the multiple moves
as price runs ahead of (or behind) earnings. Split-adjusted.
The price-to-sales ratio has risen from 13.6× (Mar '23) to 10565.0× (Nov '26).
Price / sales (P/S)
P/S
Frequently asked questions
Is LYEL growing its revenue and profit?
Over the past 5 years, Lyell Immunopharma, Inc.'s revenue has declined 65.9% per year. These are computed facts, not advice.
How much debt does LYEL have?
As of FY2025, Lyell Immunopharma, Inc. reported — of total debt against $60M of cash.
What is LYEL's profit margin?
In FY2025, gross margin was —, operating margin -748344.4%, and net margin -762355.6%.
Where does this data come from?
All figures are extracted from the company’s SEC EDGAR/XBRL filings — 10-K annual reports and 10-Q quarterly reports (use the Annual / Quarterly toggle). Quarterly figures are derived from the as-filed statements (year-to-date amounts are differenced into discrete quarters). Growth rates and ratios are computed by tradmap; nothing here is investment advice.
Source: SEC EDGAR / XBRL (10-K + 10-Q filings) · prices EOD (Databento), split-adjusted; price return — dividends not reinvested ·
growth rates, valuation multiples & ratios computed by tradmap. Valuation uses each month-end price
against the latest annual filing. Informational only — not investment advice.