IONS Ionis Pharmaceuticals Inc

$74.13 -0.15%

Healthcare · Pharmaceutical Preparations

Ionis Pharmaceuticals Inc (IONS) is a healthcare company in the Pharmaceutical Preparations industry, with a market capitalization of $12.3 billion. Shares last traded at $74.13, 14.5% below their 52-week high. Over the past year the stock is up 105.1%. Net profit margin is -40.4%, below the peer median of -0.1%. Revenue grew 33.8% year over year.

Market Cap

$12.3B

Shares Out

165.3M

EPS (TTM)

$-2.59

P/E Ratio

—

P/S Ratio

12.98

P/B Ratio

24.93

Dividend / Share

—

Dividend Yield

—

52-Week High

$86.71

52-Week Low

$36.18

Volume

63,310

Avg Vol (3m)

96,277.46

Performance

+0.46%

+0.41%

+3.95%

-5.40%

YTD

-6.88%

+105.09%

Chart

Full chart →

Daily candles · volume · SMA(20)/SMA(50) · Databento EQUS.MINI.

Technicals

RSI (14)

48.50

SMA (50)

$74.89

SMA (200)

$75.01

Price vs SMA50

-1.02%

Price vs SMA200

-1.17%

ATR (14)

$2.46

Financials

Revenue

$944M

Net Income

$-381M

Gross Margin

—

Operating Margin

-40.4%

Net Margin

-40.4%

Return on Equity

-77.6%

Return on Assets

-11.1%

Current Ratio

4.10

Debt / Equity

3.69

Revenue Growth (YoY)

+33.8%

Latest reported annual period ending 2025-12-31 · SEC EDGAR/XBRL.

Recent earnings

Period	EPS (diluted)	Reported
Q1 2026	$-0.56	2026-04-29
FY 2025	$-2.38	2026-02-26
Q3 2025	$-0.95	2025-10-29
Q2 2025	$-0.15	2025-07-30
Q1 2026	$-0.93	2026-04-29
FY 2025	$-3.04	2026-02-26

Full earnings history →

Pharmaceutical Preparations peers

IONS vs 14 industry peers (Pharmaceutical Preparations), by market cap.

P/S vs peers

12.98 / 3.54 med

+267% premium

Net margin vs peers

-40.4% / -0.1% med

below median

1–14 of 14


LLY	Lilly (Eli)	$1.04T	50.16	15.88	31.7%	-1.17%
JNJ	Johnson & Johnson	$549.8B	20.51	5.84	28.5%	-2.42%
ONC	Beone Medicines Ltd.	$390.6B	1361.26	73.10	5.4%	+2.83%
ABBV	AbbVie	$382.5B	90.51	6.25	6.9%	-2.16%
MRK	Merck	$281.6B	15.43	4.33	28.1%	-1.30%
ABT	Abbott Laboratories	$154.3B	23.65	3.48	14.7%	+0.09%
PFE	Pfizer	$143.7B	18.50	2.30	12.4%	-2.89%
VRTX	Vertex Pharmaceuticals	$114.6B	28.99	9.55	32.9%	-1.63%
BMY	Bristol Myers Squibb	$110.3B	15.63	2.29	14.6%	-2.35%
REGN	Regeneron Pharmaceuticals	$63.4B	14.08	4.42	31.4%	+0.38%
ALNY	Alnylam Pharmaceuticals	$36.9B	117.57	9.93	8.4%	-1.66%
TEVA	Teva Pharmaceutical Industries Ltd	$36.6B	25.98	2.12	8.2%	-3.33%
ZTS	Zoetis	$33.1B	12.37	3.49	28.2%	+2.09%
RPRX	Royalty Pharma Plc	$23.1B	30.02	9.73	32.4%	-1.30%

Source: SEC EDGAR (fundamentals/EPS/dividends) · Databento EQUS.MINI (prices) · market cap & yield computed by tradmap. Informational only — not financial advice.