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IONS Ionis Pharmaceuticals Inc

$41.23 -5.23%

Data as of close

Healthcare · Pharmaceutical Preparations

Ionis Pharmaceuticals Inc (IONS) is a healthcare company in the Pharmaceutical Preparations industry, with a market capitalization of $6.9 billion. Shares last traded at $41.23, 52.9% below their 52-week high. Over the past year the stock is down 44.4%. Net profit margin is -64.7%, below the peer median of -7.6%. Revenue grew 33.8% year over year.

Market Cap
$6.9B
Shares Out
166.2M
EPS (TTM)
-$3.46
P/E (TTM)*
—
P/S Ratio
7.84
P/B Ratio
15.58
Dividend / Share
—
Dividend Yield
—
52-Week High
$87.49
52-Week Low
$41.20
Volume (venue)
138,119
Avg Vol (3m, venue)
172,700.921

* P/E (TTM) = market cap ÷ net income over the trailing twelve months where four consecutive quarters are reported, otherwise the latest fiscal year — the same basis as the peer table and the screener, so it can differ from price ÷ EPS.

Performance

1W
-4.99%
1M
-5.36%
3M
-25.11%
6M
-45.36%
YTD
-47.90%
1Y
-44.41%

Daily candles · volume · SMA(20)/SMA(50) · Databento EQUS.MINI.

Technicals

RSI (14)
36.33
SMA (50)
$48.65
SMA (200)
$66.60
Price vs SMA50
-15.26%
Price vs SMA200
-38.10%
ATR (14)
$1.76

Full technical analysis (26 indicators, D/W/M) →

Financials

Revenue
$874M
Net Income
-$565M
Gross Margin
98.2%
Operating Margin
-68.0%
Net Margin
-64.7%
Return on Equity
-128.5%
Return on Assets
-18.9%
Current Ratio
7.89
Debt / Equity
4.12
Revenue Growth (YoY)
+33.8%

Trailing twelve months where four consecutive quarters are reported, otherwise the latest fiscal year; revenue is the fiscal-year figure where quarterly revenue covers under half of it (typical for banks, insurers and REITs), and margins are taken on it; latest reported period ends 2026-06-30. Source: SEC EDGAR/XBRL.

Full financials — revenue, cash flow & debt over time →

Recent earnings

PeriodEPS (diluted)Reported
Q2 2026 -$0.69 2026-07-29
Q1 2026 -$0.56 2026-04-29
Q4 2025 -$1.41 2026-02-26
FY 2025 -$2.38 2026-02-26
Q3 2025 -$0.80 2025-10-29
Q2 2025 $0.70 2025-07-30

Full earnings history →

Pharmaceutical Preparations peers

IONS vs 14 industry peers (Pharmaceutical Preparations), by market cap. Data as of close

P/S vs peers
7.84 / 7.81 med
+0% premium
Net margin vs peers
-64.7% / -7.6% med
below median
1–14 of 14
LLYLilly (Eli)$1.33T48.1315.3531.9%-0.28%
JNJJohnson & Johnson$652.2B40.526.5716.2%-0.82%
ONCBeone Medicines Ltd.$533.8B814.0587.0910.7%-2.48%
ABBVAbbVie$510.3B80.877.939.8%-2.05%
MRKMerck$366.4B115.465.504.8%-0.22%
ABTAbbott Laboratories$192.1B30.614.2613.9%+3.81%
PFEPfizer$175.0B40.412.756.8%+0.69%
VRTXVertex Pharmaceuticals$144.5B32.8011.4835.0%+1.96%
BMYBristol Myers Squibb$128.8B13.942.5818.5%+0.90%
REGNRegeneron Pharmaceuticals$99.4B20.645.8928.5%+3.63%
TEVATeva Pharmaceutical Industries Ltd$47.4B67.142.744.1%-3.35%
ZTSZoetis$34.4B13.143.6127.5%+4.35%
RPRXRoyalty Pharma Plc$29.6B36.3511.6832.1%-0.98%
ROIVRoivant Sciences Ltd.$25.9B—3441.87—-2.76%

Source: SEC EDGAR (fundamentals/EPS/dividends) · Databento EQUS.MINI (prices) · market cap & yield computed by tradmap. Informational only — not financial advice.