6 years of revenue, profit, cash flow and balance-sheet history through FY2025,
from SEC filings — with a computed, factual read of the trend.
Updated Overview →
Growth & profitability
Revenue has declined 2.3% per year over the past 5 years.
Operating margin has contracted, at -4498.1% in the latest year.
Financial health
The company is unprofitable and has less than a year of cash runway at its current free-cash-flow burn.
Revenue & net income
RevenueNet income
Margins (gross / operating / net)
GrossOperatingNet
Free cash flow (CFO − capex)
Free cash flow
Cash vs total debt
CashTotal debt
Cash flow: operating / investing / financing
OperatingInvestingFinancing
Key annual figures
FY
Revenue
Net income
Gross M
Op M
FCF
Total debt
Cash
2025
$5M
-$201M
0.0%
-4498.1%
-$167M
—
$63M
2024
$3M
-$196M
0.0%
-6787.4%
-$130M
—
$182M
2023
$0
-$198M
—
—
-$174M
—
$42M
2022
$0
-$122M
—
—
-$148M
—
$188M
2021
$0
-$165M
—
—
-$38M
—
$185M
2020
$5M
-$3M
0.0%
-17.9%
-$6M
—
$37M
Revenue & net income
RevenueNet income
Margins (gross / operating / net)
GrossOperatingNet
Free cash flow (CFO − capex, quarterly)
Free cash flow
Cash vs total debt
CashTotal debt
Cash flow: operating / investing / financing
OperatingInvestingFinancing
Key quarterly figures
Quarter
Revenue
Net income
Gross M
Op M
FCF
Total debt
Cash
Mar '26
—
-$49M
—
—
-$43M
—
$64M
Dec '25
$838000
-$46M
0.0%
-5800.5%
-$38M
—
$63M
Sep '25
$1M
-$51M
0.0%
-4406.0%
-$35M
—
$71M
Jun '25
$1M
-$53M
0.0%
-4787.2%
-$43M
—
$54M
Mar '25
$1M
-$52M
0.0%
-3603.3%
-$51M
—
$92M
Dec '24
$2M
-$42M
0.0%
-2025.7%
$14M
—
$182M
Sep '24
$209000
-$53M
0.0%
-25948.3%
-$27M
—
$118M
Jun '24
$0
-$55M
—
—
-$47M
—
$56M
Mar '24
$591000
-$46M
0.0%
-8179.5%
-$70M
—
$94M
Dec '23
$0
-$66M
—
—
-$46M
—
$42M
Sep '23
$0
-$51M
—
—
-$42M
—
$44M
Jun '23
$0
-$42M
—
—
-$43M
—
$121M
Mar '23
$0
-$39M
—
—
-$44M
—
$133M
Dec '22
—
-$39M
—
—
-$36M
—
$188M
Sep '22
—
-$29M
—
—
-$35M
—
$48M
Jun '22
—
-$29M
—
—
-$25M
—
$92M
Mar '22
—
-$24M
—
—
-$52M
—
$164M
Dec '21
—
-$63M
—
—
-$14M
—
$185M
Sep '21
—
-$16M
—
—
—
—
$201M
Jun '21
—
$616000
—
—
—
—
—
Valuation over time
How the market has priced PRME against its own fundamentals since 2023-03 —
each month-end's share price set against the most recent annual filing, so the multiple moves
as price runs ahead of (or behind) earnings. Split-adjusted.
The price-to-sales ratio has fallen from 176.8× (Dec '24) to 124.0× (Jun '26).
Price / sales (P/S)
P/S
Frequently asked questions
Is PRME growing its revenue and profit?
Over the past 5 years, Prime Medicine, Inc.'s revenue has declined 2.3% per year. These are computed facts, not advice.
How much debt does PRME have?
As of FY2025, Prime Medicine, Inc. reported — of total debt against $63M of cash.
What is PRME's profit margin?
In FY2025, gross margin was —, operating margin -4498.1%, and net margin -4342.4%.
Where does this data come from?
All figures are extracted from the company’s SEC EDGAR/XBRL filings — 10-K annual reports and 10-Q quarterly reports (use the Annual / Quarterly toggle). Quarterly figures are derived from the as-filed statements (year-to-date amounts are differenced into discrete quarters). Growth rates and ratios are computed by tradmap; nothing here is investment advice.
Source: SEC EDGAR / XBRL (10-K + 10-Q filings) · prices EOD (Databento), corporate-action-adjusted ·
growth rates, valuation multiples & ratios computed by tradmap. Valuation uses each month-end price
against the latest annual filing. Informational only — not investment advice.