15 years of revenue, profit, cash flow and balance-sheet history through FY2025,
from SEC filings — with a computed, factual read of the trend.
Updated Overview →
Growth & profitability
Revenue has declined 3.5% per year over the past 5 years.
Operating margin has contracted, at -10.4% in the latest year.
Financial health
Total debt has grown slower than revenue (-48.2% vs -3.5% per year).
The company is unprofitable; at its current free-cash-flow burn it has roughly 1.1 years of cash runway.
Revenue & net income
RevenueNet income
Margins (gross / operating / net)
GrossOperatingNet
Return on equity & assets (ROE / ROA)
ROEROA
Free cash flow (CFO − capex)
Free cash flow
Cash vs total debt
CashTotal debt
Cash flow: operating / investing / financing
OperatingInvestingFinancing
Key annual figures
FY
Revenue
Net income
Gross M
Op M
ROE
ROA
FCF
Total debt
Cash
2025
$53M
-$7M
48.8%
-10.4%
-13.7%
-8.0%
-$14M
—
$15M
2024
$53M
$3M
54.5%
7.3%
6.8%
4.0%
$7M
—
$20M
2023
$65M
$8M
64.9%
16.0%
24.8%
9.8%
-$2M
—
$24M
2022
$48M
-$15M
58.9%
-27.3%
140.3%
-26.8%
-$26M
—
$17M
2021
$38M
-$28M
57.4%
-53.4%
457.0%
-37.4%
-$12M
—
$39M
2020
$63M
-$7M
82.7%
4.3%
24.1%
-9.6%
-$27M
—
$18M
2019
$55M
-$18M
80.1%
-19.6%
26.0%
-40.3%
-$20M
—
$18M
2018
$34M
-$26M
72.8%
-56.4%
50.0%
-43.3%
-$8M
—
$38M
2017
$21M
-$83M
19.0%
-163.8%
283.3%
-115.5%
-$11M
—
$51M
2016
$9M
-$29M
8.7%
-360.5%
294.9%
-35.7%
-$33M
—
$63M
2015
$4M
$58M
83.3%
-542.4%
533.8%
59.7%
-$25M
—
$76M
2014
$4M
-$30M
82.1%
-810.6%
53.9%
-38.2%
-$30M
$912000
$55M
2013
$0
-$28M
—
—
103.1%
-24.5%
-$33M
$2M
$86M
2012
$35M
-$12M
75.4%
-34.9%
346.1%
-14.8%
-$1M
$5M
$52M
2011
$8M
-$37M
17.2%
-435.6%
140.1%
-70.5%
-$29M
$7M
$27M
Revenue & net income
RevenueNet income
Margins (gross / operating / net)
GrossOperatingNet
Return on equity & assets (ROE / ROA)
ROEROA
Free cash flow (CFO − capex, quarterly)
Free cash flow
Cash vs total debt
CashTotal debt
Cash flow: operating / investing / financing
OperatingInvestingFinancing
Key quarterly figures
Quarter
Revenue
Net income
Gross M
Op M
ROE
ROA
FCF
Total debt
Cash
Jun '26
$20M
$4M
61.0%
23.5%
5.3%
3.4%
-$11M
—
$27M
Mar '26
$34M
$18M
87.8%
62.7%
27.2%
17.9%
$21M
—
$41M
Dec '25
$9M
-$6M
49.4%
-51.1%
-11.4%
-6.7%
$2M
—
$15M
Sep '25
$18M
$2M
53.4%
11.9%
4.5%
2.9%
-$4M
—
$14M
Jun '25
$16M
$164000
62.5%
7.5%
0.3%
0.2%
-$6M
—
$18M
Mar '25
$10M
-$4M
19.1%
-41.0%
-8.0%
-4.9%
-$5M
—
$19M
Dec '24
$18M
$6M
78.7%
39.6%
15.0%
8.8%
$4M
—
$20M
Sep '24
$18M
$3M
53.4%
22.2%
10.0%
5.3%
$4M
—
$27M
Jun '24
$13M
-$2M
29.8%
-18.0%
-7.7%
-2.4%
-$4M
—
$23M
Mar '24
$4M
-$5M
30.6%
-129.6%
-15.4%
-5.1%
$4M
—
$27M
Dec '23
$10M
-$6M
15.5%
-53.5%
-18.0%
-7.2%
$3M
—
$24M
Sep '23
$10M
-$2M
52.7%
-18.2%
-4.8%
-2.1%
-$7M
—
$20M
Jun '23
$35M
$19M
82.5%
58.2%
49.6%
21.9%
$5M
—
$48M
Mar '23
$10M
-$3M
67.8%
-25.6%
-310.6%
-4.7%
-$3M
—
$33M
Dec '22
$9M
-$4M
72.2%
-29.0%
35.2%
-6.7%
-$3M
—
$17M
Sep '22
$14M
-$4M
50.1%
-22.0%
31.0%
-6.3%
-$9M
—
$11M
Jun '22
$9M
-$5M
53.3%
-63.1%
53.9%
-8.8%
-$7M
—
$12M
Mar '22
$16M
-$2M
62.5%
-11.6%
30.5%
-3.3%
-$6M
—
$17M
Dec '21
$9M
-$7M
63.2%
-66.7%
110.5%
-9.1%
-$6M
—
$39M
Sep '21
$12M
-$4M
69.3%
-15.6%
-1971.4%
-5.0%
-$2M
—
$11M
Valuation over time
How the market has priced PLX against its own fundamentals since 2023-03 —
each month-end's share price set against the most recent annual filing, so the multiple moves
as price runs ahead of (or behind) earnings. Split-adjusted.
The price-to-earnings ratio has risen from 14.2× (Jan '24) to 49.2× (Nov '25).
The price-to-sales ratio has risen from 3.6× (Mar '23) to 4.0× (Nov '26).
Price / earnings (P/E)
P/E
Price / sales (P/S)
P/S
Frequently asked questions
Is PLX growing its revenue and profit?
Over the past 5 years, Protalix BioTherapeutics, Inc.'s revenue has declined 3.5% per year. These are computed facts, not advice.
How much debt does PLX have?
As of FY2025, Protalix BioTherapeutics, Inc. reported — of total debt against $15M of cash.
What is PLX's profit margin?
In FY2025, gross margin was 48.8%, operating margin -10.4%, and net margin -12.5%.
What is PLX's P/E ratio?
Protalix BioTherapeutics, Inc.'s P/E (TTM) is 11.08 as of the 2026-11-03 close — market cap ÷ net income over the trailing twelve months where four consecutive quarters are reported, otherwise the latest fiscal year, the same figure as on the PLX stock page. The valuation chart above sets each month-end's price against the latest annual net income instead, so its latest point (about 49.2× as of Nov '26) can differ. These are computed facts, not advice.
Where does this data come from?
All figures are extracted from the company’s SEC EDGAR/XBRL filings — 10-K annual reports and 10-Q quarterly reports (use the Annual / Quarterly toggle). Quarterly figures are derived from the as-filed statements (year-to-date amounts are differenced into discrete quarters). Growth rates and ratios are computed by tradmap; nothing here is investment advice.
Source: SEC EDGAR / XBRL (10-K + 10-Q filings) · prices EOD (Databento), split-adjusted; price return — dividends not reinvested ·
growth rates, valuation multiples & ratios computed by tradmap. Valuation uses each month-end price
against the latest annual filing. Informational only — not investment advice.